Controlling adherence to a gluten-free diet is essential for improving the quality of life and preventing long-term complications in patients with celiac disease.
However, dietary questionnaires are not sufficiently reliable tools for evaluating adherence. Instead, the combination of serology and urinary GIP detection may provide a more comprehensive assessment. This was demonstrated in a study presented at the International Celiac Disease Symposium, ICDS 2022, which recruited 277 celiac patients and evaluated the correlation between different adherence control tools.
The conclusions of this study were as follows:
👉 Urinary GIP detection is significantly associated with serology (positive IgA-EMA, IgA-tTG) and the presence of intestinal villous atrophy in celiac patients.
👉 Gluten-free diet adherence questionnaires do not correlate with serological markers IgA-EMA, IgA-tTG, urinary GIP detection, or the presence of villous atrophy.
Therefore, this study demonstrates that dietary questionnaires are not the most reliable tool for evaluating adherence to a gluten-free diet in people with celiac disease. However, in combination with other evaluation methods, such as serology and urinary GIP markers, they may serve as a helpful tool to provide a more comprehensive assessment.
Reference: Raju et al. Can Self-reported, serological and urinary markers for gluten identify active coeliac disease?. Poster presented at: ICDS 2022. 19th International Celiac Disease Symposium; 2022 Oct 19-22; Sorrento, Italy.